TOPMed Imputation Server

TOPMed Imputation Server provides a free genotype imputation service using Minimac4. You can upload phased or unphased GWAS genotypes and receive phased and imputed genomes in return. This server offers imputation from the TOPMed reference panel. For all uploaded datasets an extensive QC is performed.

Please cite this paper if you use the TOPMed Imputation Server in your publication:

Das S, Forer L, Schönherr S, Sidore C, Locke AE, Kwong A, Vrieze S, Chew EY, Levy S, McGue M, Schlessinger D, Stambolian D, Loh PR, Iacono WG, Swaroop A, Scott LJ, Cucca F, Kronenberg F, Boehnke M, Abecasis GR, Fuchsberger C. Next-generation genotype imputation service and methods. Nature Genetics 48, 1284–1287 (2016).

The complete source code is hosted on GitHub using Travis CI for continuous integration.